SnapShot: Antibiotic Inhibition of Protein Synthesis I

@article{Sohmen2009SnapShotAI,
  title={SnapShot: Antibiotic Inhibition of Protein Synthesis I},
  author={Daniel Sohmen and Joerg M. Harms and Frank Schluenzen and Daniel N. Wilson},
  journal={Cell},
  year={2009},
  volume={138},
  pages={1248-1248.e1}
}
Elongation (translocation) Most aminoglycoside antibiotics induce translational misreading by promoting binding of near-cognate tRNAs, but the biological effect is probably due to inhibition of the translocation reaction and promotion of back-translocation. Edeine Edeine A Initiation (fMet-tRNA binding) Edeine prevents binding of the initiator tRNA to the 30S subunit in an mRNA-dependent manner. GE81112 GE81112 Initiation (fMet-tRNA binding) GE81112 inhibits binding of the initiator tRNA to the… CONTINUE READING

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