Snail1 mediates hypoxia-induced melanoma progression.

  title={Snail1 mediates hypoxia-induced melanoma progression.},
  author={Shujing Liu and Suresh M. Kumar and James S. Martin and Ruifeng Yang and Xiaowei Xu},
  journal={The American journal of pathology},
  volume={179 6},
Tumor hypoxia is a known adverse prognostic factor, and the hypoxic dermal microenvironment participates in melanomagenesis. High levels of hypoxia inducible factor (HIF) expression in melanoma cells, particularly HIF-2α, is associated with poor prognosis. The mechanism underlying the effect of hypoxia on melanoma progression, however, is not fully understood. We report evidence that the effects of hypoxia on melanoma cells are mediated through activation of Snail1. Hypoxia increased melanoma… CONTINUE READING
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