Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer

@article{Ni2016Snail1dependentPR,
  title={Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer},
  author={Ting Ni and Xiao-yan Li and Na Lu and Teng An and Zhi-Ping Liu and Rong Fu and Wen-Cong Lv and Yingyuan Zhang and Xiao-jun Xu and R. Grant Rowe and Yong-Shun Lin and Amanda Elo{\'i}na Scherer and Tamar Feinberg and Xiao-qi Zheng and Bao-an Chen and Xiaole Shirley Liu and Qing-long Guo and Zhao-Qiu Wu and Stephen J Weiss},
  journal={Nature Cell Biology},
  year={2016},
  volume={18},
  pages={1221-1232}
}
The zinc-finger transcription factor Snail1 is inappropriately expressed in breast cancer and associated with poor prognosis. While interrogating human databases, we uncovered marked decreases in relapse-free survival of breast cancer patients expressing high Snail1 levels in tandem with wild-type, but not mutant, p53. Using a Snail1 conditional knockout model of mouse breast cancer that maintains wild-type p53, we find that Snail1 plays an essential role in tumour progression by controlling… CONTINUE READING

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