Snail1 controls TGF-β responsiveness and differentiation of Mesenchymal Stem Cells

@inproceedings{Batlle2013Snail1CT,
  title={Snail1 controls TGF-β responsiveness and differentiation of Mesenchymal Stem Cells},
  author={Raquel Batlle and Lorena Alba-Castell{\'o}n and Jordina Loubat-Casanovas and Elena Armenteros and Clara Franc{\'i} and Jelena Stanisavljevic and Rodrigo Banderas and Juan Mart{\'i}n-Caballero and F{\'e}lix Bonilla and Josep Baulida and J Ignacio Casal and Thomas Gridley and Antonio Garc{\'i}a de Herreros},
  booktitle={Oncogene},
  year={2013}
}
The Snail1 transcriptional repressor plays a key role in triggering epithelial-to-mesenchymal transition. Although Snail1 is widely expressed in early development, in adult animals it is limited to a subset of mesenchymal cells where it has a largely unknown function. Using a mouse model with inducible depletion of Snail1, here we demonstrate that Snail1 is required to maintain mesenchymal stem cells (MSCs). This effect is associated to the responsiveness to transforming growth factor (TGF)-β1… CONTINUE READING

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