Snail transcription factor regulates neuroendocrine differentiation in LNCaP prostate cancer cells.

@article{Mckeithen2010SnailTF,
  title={Snail transcription factor regulates neuroendocrine differentiation in LNCaP prostate cancer cells.},
  author={Danielle Mckeithen and Tisheeka R. Graham and Leland W. K. Chung and Valerie Odero-Marah},
  journal={The Prostate},
  year={2010},
  volume={70 9},
  pages={982-92}
}
BACKGROUND Snail transcription factor induces epithelial-mesenchymal transition (EMT) via decreased cell adhesion-associated molecules like E-cadherin, and increased mesenchymal markers like vimentin. We previously established Snail-mediated EMT model utilizing androgen-dependent LNCaP cells. These cells express increased vimentin protein and relocalization of E-cadherin from the cell membrane to the cytosol. Interestingly, Snail transfection in LNCaP cells resulted in cells acquiring a… CONTINUE READING