Snail silencing effectively suppresses tumour growth and invasiveness

  title={Snail silencing effectively suppresses tumour growth and invasiveness},
  author={David Olmeda and Mireia Jord{\`a} and H{\'e}ctor Peinado and {\'A}ngels Fabra and A Barbado Cano},
The transcription factor Snail has been recently proposed as an important mediator of tumour invasion because of its role in downregulation of E-cadherin and induction of epithelial–mesenchymal transitions (EMT). This behaviour has led to the consideration of Snail as a potential therapeutic target to block tumour progression. In this report, we provide evidence for this hypothesis. We show that silencing of Snail by stable RNA interference in MDCK-Snail cells induces a complete mesenchymal to… CONTINUE READING
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