Snail regulates Nanog status during the epithelial–mesenchymal transition via the Smad1/Akt/GSK3β signaling pathway in non-small-cell lung cancer

@inproceedings{Liu2014SnailRN,
  title={Snail regulates Nanog status during the epithelial–mesenchymal transition via the Smad1/Akt/GSK3β signaling pathway in non-small-cell lung cancer},
  author={Chen-Wei Liu and Ching-Hao Li and Peng Yi-Jen and Y B Cheng and H. W. Chen and Po-Lin Liao and J J Kang and Mao-Hsiung Yeng},
  booktitle={Oncotarget},
  year={2014}
}
The epithelial-mesenchymal transition (EMT), a crucial step in cancer metastasis, is important in transformed cancer cells with stem cell-like properties. In this study, we established a Snail-overexpressing cell model for non-small-cell lung cancer (NSCLC) and investigated its underlying mechanism. We also identified the downstream molecular signaling pathway that contributes to the role of Snail in regulating Nanog expression. Our data shows that high levels of Snail expression correlate with… CONTINUE READING