Snail recruits Ring1B to mediate transcriptional repression and cell migration in pancreatic cancer cells.

@article{Chen2014SnailRR,
  title={Snail recruits Ring1B to mediate transcriptional repression and cell migration in pancreatic cancer cells.},
  author={Jiangzhi Chen and Hong Xu and Xiuqun Zou and Jiamin Wang and Yi Zhu and Hao Chen and Baiyong Shen and Xiaxing Deng and Aiwu Zhou and Y Eugene Chin and F. Rauscher and Cheng-Hong Peng and Zhaoyuan Hou},
  journal={Cancer research},
  year={2014},
  volume={74 16},
  pages={4353-63}
}
Transcriptional repressor Snail is a master regulator of epithelial-mesenchymal transition (EMT), yet the epigenetic mechanism governing Snail to induce EMT is not well understood. Here, we report that in pancreatic ductal adenocarcinoma (PDAC), elevated levels of the ubiquitin E3 ligase Ring1B and Snail, along with elevated monoubiquitination of H2A at K119 (H2AK119Ub1), are highly correlated with poor survival. Mechanistic investigations identified Ring1B as a Snail-interacting protein and… CONTINUE READING
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