Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression.

@article{Guaita2002SnailIO,
  title={Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression.},
  author={Sandra Guaita and Isabel Puig and Clara Franc{\'i} and Marta Garrido and David J. Dominguez and Eduard Batlle and E. P{\'e}rez Sancho and Shoukat Dedhar and Antonio Garc{\'i}a de Herreros and Josep Baulida},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 42},
  pages={39209-16}
}
E-cadherin protein plays a key role in the establishment and maintenance of adherent junctions. Recent evidence implicates the transcription factor Snail in the blockage of E-cadherin expression in fibroblasts and some epithelial tumor cells through direct binding to three E-boxes in the E-cadherin promoter. Transfection of Snail into epithelial cells leads to a more fibroblastic phenotype. Cells expressing Snail presented a scattered flattened phenotype with low intercellular contacts. Other… CONTINUE READING
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