Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b.

@article{Hu2010SnailAW,
  title={Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b.},
  author={Chi-Tan Hu and Tsu-Yao Chang and Chuan-Chu Cheng and Chun-Shan Liu and Jia-Ru Wu and M Li and W S Wu},
  journal={The FEBS journal},
  year={2010},
  volume={277 5},
  pages={1202-18}
}
Snail is a multifunctional transcriptional factor that has been described as a repressor in many different contexts. It is also proposed as an activator in a few cases relevant to tumor progression and cell-cycle arrest. This study investigated the detailed mechanisms by which Snail upregulates gene expression of the CDK inhibitor p15(INK4b) in HepG2 induced by the tumor promoter tetradecanoyl phorbol acetate (TPA). Using deletion mapping, the TPA-responsive element on the p15(INK4b) promoter… CONTINUE READING
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