Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells

@article{Miyoshi2004SnailAS,
  title={Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells},
  author={Atsushi Kubota Ikuo Miyoshi and Yoshihiko Kitajima and Kenji Sumi and Ken Sato and Atsushi Hagiwara and Yasuo Koga and Keiko Miyazaki},
  journal={British Journal of Cancer},
  year={2004},
  volume={90},
  pages={1265 - 1273}
}
Loss of E-cadherin (E-cad) triggers invasion, metastasis, and dedifferentiation in various epithelial carcinomas. Recently, it has been reported that two transcription factors, Snail and SIP1 (Smad interacting protein 1), directly repress transcription of the E-cad gene by binding E-box on E-cad promoter. Our aim is to solve the molecular mechanism of Snail and SIP1 in hepatocellular carcinoma (HCC). We first showed an inverse correlation between E-cad and Snail/SIP 1 expression among five HCC… CONTINUE READING