Smyth Signaling During Platelet Adhesion and Activation

  title={Smyth Signaling During Platelet Adhesion and Activation},
  author={Zhenyu Li and Michael Keegan Delaney and Kelly A. O’Brien and Xiaoping Du},
Upon vascular injury, platelets are activated by adhesion to adhesive proteins, such as von Willebrand factor and collagen, or by soluble platelet agonists, such as ADP, thrombin, and thromboxane A2. These adhesive proteins and soluble agonists induce signal transduction via their respective receptors. The various receptor-specific platelet activation signaling pathways converge into common signaling events that stimulate platelet shape change and granule secretion and ultimately induce the… CONTINUE READING


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