Smyd3-associated regulatory pathways in cancer.

Abstract

SMYD3 is a member of the SET and MYND-domain family of methyl-transferases, the increased expression of which correlates with poor prognosis in various types of cancer. In liver and colon tumors, SMYD3 is localized in the nucleus, where it interacts with RNA Pol II and H3K4me3 and functions as a selective transcriptional amplifier of oncogenes and genes… (More)
DOI: 10.1016/j.semcancer.2016.08.008

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