Smyd3 Is Required for the Development of Cardiac and Skeletal Muscle in Zebrafish

  title={Smyd3 Is Required for the Development of Cardiac and Skeletal Muscle in Zebrafish},
  author={Tomoaki Fujii and Shin-ichiro Tsunesumi and Kiyoshi Yamaguchi and Sumiko Watanabe and Yoichi Furukawa},
  booktitle={PloS one},
Modifications of histone tails are involved in the regulation of a wide range of biological processes including cell cycle, cell survival, cell division, and cell differentiation. Among the modifications, histone methylation plays a critical role in cardiac and skeletal muscle differentiation. In our earlier studies, we found that SMYD3 has methyltransferase activity to histone H3 lysine 4, and that its up-regulation is involved in the tumorigenesis of human colon, liver, and breast. To clarify… CONTINUE READING
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