Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1

@inproceedings{Ramkumar2013Smurf2SB,
  title={Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1},
  author={Charusheila Ramkumar and Hang Cui and Yahui Kong and Stephen N. Jones and Rachel M. Gerstein and Hong Zhang},
  booktitle={Nature communications},
  year={2013}
}
About half of patients with diffuse large B-cell lymphoma (DLBCL) do not respond to or relapse soon after the standard chemotherapy, indicating a critical need to better understand the specific pathways perturbed in DLBCL for developing effective therapeutic approaches. Mice deficient in the E3 ubiquitin ligase Smurf2 spontaneously develop B-cell lymphomas… CONTINUE READING

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