Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail.

@article{Jia2003SmoothenedTH,
  title={Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail.},
  author={Jianhang Jia and Chao Tong and Jin Jiang},
  journal={Genes & development},
  year={2003},
  volume={17 21},
  pages={2709-20}
}
The Hedgehog (Hh) family of secreted proteins controls many aspects of growth and patterning in animal development. The seven-transmembrane protein Smoothened (Smo) transduces the Hh signal in both vertebrates and invertebrates; however, the mechanism of its action remains unknown. We found that Smo lacking its C-terminal tail (C-tail) is inactive, whereas membrane-tethered Smo C-tail has constitutive albeit low levels of Hh signaling activity. Smo physically interacts with Costal2 (Cos2) and… CONTINUE READING
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