Smoothened as a new therapeutic target for human osteosarcoma

@inproceedings{Hirotsu2009SmoothenedAA,
  title={Smoothened as a new therapeutic target for human osteosarcoma},
  author={Masataka Hirotsu and Takao Setoguchi and Hiromi Sasaki and Yukihiro Matsunoshita and Hui Gao and Hiroko Nagao and Osamu Kunigou and Setsuro Komiya},
  booktitle={Molecular Cancer},
  year={2009}
}
The Hedgehog signaling pathway functions as an organizer in embryonic development. Recent studies have demonstrated constitutive activation of Hedgehog pathway in various types of malignancies. However, it remains unclear how Hedgehog pathway is involved in the pathogenesis of osteosarcoma. To explore the involvement of aberrant Hedgehog pathway in the pathogenesis of osteosarcoma, we investigated the expression and activation of Hedgehog pathway in osteosarcoma and examined the effect of… CONTINUE READING

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