Smoothened agonist augments proliferation and survival of neural cells

@article{Bragina2010SmoothenedAA,
  title={Smoothened agonist augments proliferation and survival of neural cells},
  author={O. Bragina and S. Sergejeva and M. Serg and Tamara Žarkovsky and Alla Maloverjan and P. Kogerman and Aleksandr Žarkovsky},
  journal={Neuroscience Letters},
  year={2010},
  volume={482},
  pages={81-85}
}
Sonic hedgehog signaling pathway is important in developmental processes like dorsoventral neural tube patterning, neural stem cell proliferation and neuronal and glial cell survival. Shh is also implicated in the regulation of the adult hippocampal neurogenesis. Recently, nonpeptidyl Smoothened activators of the Shh pathway have been identified. The aim of this study was to investigate the effects of chlorobenzothiophene-containing molecule, Smo agonist (SAG), which has been shown to activate… Expand
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