Smoothelin-like 1 protein is a bifunctional regulator of the progesterone receptor during pregnancy.

Abstract

During pregnancy, uterine smooth muscle (USM) coordinately adapts its contractile phenotype in order to accommodate the developing fetus and then prepare for delivery. Herein we show that SMTNL1 plays a major role in pregnancy to promote adaptive responses in USM and that this process is specifically mediated through interactions of SMTNL1 with the steroid… (More)
DOI: 10.1074/jbc.M111.270397

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