Smooth-pursuit eye movements, and diazepam, CPZ, and secobarbital

  title={Smooth-pursuit eye movements, and diazepam, CPZ, and secobarbital},
  author={Philip S. Holzman and Deborah L. Levy and Eberhard H. Uhlenhuth and Leonard R. Proctor and Daniel X. Freedman},
This study examined the effects on smooth-pursuit eye tracking of single doses of CPZ (0.667 and 1.334 mg/kg), diazepam (0.071, 0.142, and 0.284 mg/kg), and secobarbital (100 mg). Only the barbiturate significantly affected the ability to follow a moving target with smooth-pursuit eye movements. In repeated testing of a single subject, 130 mg of secobarbital disrupted smooth-pursuit movements at least until 24 hrs after ingestion. 

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