Smooth muscle-targeted knockout of connexin43 enhances neointimal formation in response to vascular injury.

@article{Liao2007SmoothMK,
  title={Smooth muscle-targeted knockout of connexin43 enhances neointimal formation in response to vascular injury.},
  author={Yongbo Liao and C. Pandu Regan and Ichiro Manabe and Gary K. Owens and Kathy H. Day and Dave N. Damon and Brian R. Duling},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2007},
  volume={27 5},
  pages={1037-42}
}
OBJECTIVE Vascular disease alters and reduces connexin expression and a reduction in connexin 43 (Cx43) expression diminishes the extent of atherosclerosis observed in a high-cholesterol diet murine model. We hypothesized that connexins might play a role in the smooth muscle cell response to vascular injury. METHODS AND RESULTS We therefore studied a line of smooth muscle cell-specific, Cx43 gene knockout mice (SM Cx43 KO) in which the carotid arteries were injured, either by vascular… CONTINUE READING