Smooth muscle guanine nucleotides and receptor-effector coupling following inhibition of oxidative energy production.

@article{Coburn1993SmoothMG,
  title={Smooth muscle guanine nucleotides and receptor-effector coupling following inhibition of oxidative energy production.},
  author={Ronald F. Coburn and Shaukath Azim and W. S. Fillers and Carl B Baron},
  journal={The American journal of physiology},
  year={1993},
  volume={264 1 Pt 1},
  pages={L1-6}
}
We measured total concentrations of guanosine triphosphate (GTP) and guanosine diphosphate (GDP) in rabbit aortic smooth muscle under several different conditions. We computed free [GDP] and free GTP/GDP (using a Keq of 1.0 for the nucleoside diphosphate kinase reduction) under these conditions. At a time when muscle was contracted by 15 microM norepinephrine (NE) for 5 min under normoxia, [GTP], free [GDP], and free GTP/GDP were 0.29 +/- 0.03 mM, 3.5 microM, and 82, respectively. Following… CONTINUE READING
2 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.

Similar Papers

Loading similar papers…