Smooth muscle-generated methylglyoxal impairs endothelial cell-mediated vasodilatation of cerebral microvessels in type 1 diabetic rats.

Abstract

BACKGROUND AND PURPOSE Endothelial cell-mediated vasodilatation of cerebral arterioles is impaired in individuals with Type 1 diabetes (T1D). This defect compromises haemodynamics and can lead to hypoxia, microbleeds, inflammation and exaggerated ischaemia-reperfusion injuries. The molecular causes for dysregulation of cerebral microvascular endothelial… (More)
DOI: 10.1111/bph.13617

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Cite this paper

@article{Alomar2016SmoothMM, title={Smooth muscle-generated methylglyoxal impairs endothelial cell-mediated vasodilatation of cerebral microvessels in type 1 diabetic rats.}, author={Fadhel Alomar and Jaipaul Singh and Hee-Seong Jang and George J Rozanzki and Chun Hong Shao and Babu J Padanilam and William G Mayhan and Keshore R. Bidasee}, journal={British journal of pharmacology}, year={2016}, volume={173 23}, pages={3307-3326} }