Smooth muscle cells in transplant atherosclerotic lesions are originated from recipients, but not bone marrow progenitor cells.

@article{Hu2002SmoothMC,
  title={Smooth muscle cells in transplant atherosclerotic lesions are originated from recipients, but not bone marrow progenitor cells.},
  author={Yanhua Hu and Fergus Davison and Burkhard Ludewig and Martin Erdel and Manuel Mayr and Manfred Url and Hermann Dietrich and Qingbo Xu},
  journal={Circulation},
  year={2002},
  volume={106 14},
  pages={1834-9}
}
BACKGROUND Smooth muscle cell (SMC) accumulation in the intima of vessels is a key event in the pathogenesis of transplant atherosclerosis. The traditional hypothesis that SMCs in the lesion are derived from the media of the donor vessel has been challenged by recent observations, but the cell origin is still not well established. METHODS AND RESULTS Here, we use a simplified model of artery allografts in transgenic mice to clearly identify the source of SMCs in transplant atherosclerosis… CONTINUE READING

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