Smooth muscle cell transient receptor potential polycystin-2 (TRPP2) channels contribute to the myogenic response in cerebral arteries.

@article{Narayanan2013SmoothMC,
  title={Smooth muscle cell transient receptor potential polycystin-2 (TRPP2) channels contribute to the myogenic response in cerebral arteries.},
  author={Damodaran Narayanan and Simon Bulley and M Dennis Leo and Sarah K. Burris and Kyle S. Gabrick and Frederick A. Boop and Jonathan H Jaggar},
  journal={The Journal of physiology},
  year={2013},
  volume={591 20},
  pages={5031-46}
}
Intravascular pressure-induced vasoconstriction is a smooth muscle cell-specific mechanism that controls systemic blood pressure and organ regional blood flow. Smooth muscle cell polycystin-1 and -2 (TRPP1 and -2) proteins modulate the myogenic response in mesenteric arteries, but involvement in other vascular beds is unclear. Here, we examined TRPP2 expression, cellular distribution, cation currents (ICat), and physiological functions in smooth muscle cells of rat and human cerebral arteries… CONTINUE READING
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