Smooth muscle cell immediate-early gene and growth factor activation follows vascular injury. A putative in vivo mechanism for autocrine growth.

@article{Miano1993SmoothMC,
  title={Smooth muscle cell immediate-early gene and growth factor activation follows vascular injury. A putative in vivo mechanism for autocrine growth.},
  author={Joseph M. Miano and N Vlasic and Robert Tota and Michael B. Stemerman},
  journal={Arteriosclerosis and thrombosis : a journal of vascular biology},
  year={1993},
  volume={13 2},
  pages={211-9}
}
To understand the molecular events governing smooth muscle cell (SMC) proliferation in vivo, immediate-early gene (IEG) expression was assessed and related to growth factor ligand and receptor mRNA and SMC DNA synthesis after aortic injury. Balloon catheter injury evoked increases in SMC c-myc and thrombospondin (tsp) within 2 hours. The induction of these IEGs was followed by elevated transcripts to platelet-derived growth factor-A (PDGF-A), transforming growth factor-beta 1 (TGF-beta 1) and a… CONTINUE READING

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