Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP.

@article{Morita1995SmoothMC,
  title={Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP.},
  author={Takashi Morita and Mark A. Perrella and Margaret E. Lee and Stella Kourembanas},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 5},
  pages={1475-9}
}
Carbon monoxide (CO) is a product of the enzyme heme oxygenase (HO; EC 1.14.99.3). In vascular smooth muscle cells, exogenously administered CO increases cyclic guanosine 3',5'-monophosphate (cGMP), which is an important regulator of vessel tone. We report here that smooth muscle cells produce CO via HO and that it regulates cGMP levels in these cells. Hypoxia, which has profound effects on vessel tone, significantly increased the transcriptional rate of the HO-1 gene resulting in corresponding… CONTINUE READING
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