Smooth muscle cell deletion of low-density lipoprotein receptor-related protein 1 augments angiotensin II-induced superior mesenteric arterial and ascending aortic aneurysms.

@article{Davis2015SmoothMC,
  title={Smooth muscle cell deletion of low-density lipoprotein receptor-related protein 1 augments angiotensin II-induced superior mesenteric arterial and ascending aortic aneurysms.},
  author={Frank M Davis and Debra L. Rateri and Anju Balakrishnan and Deborah A. Howatt and Dudley K Strickland and Selen C Muratoglu and Christopher M. Haggerty and Brandon K. Fornwalt and Lisa A. Cassis and Alan Daugherty},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2015},
  volume={35 1},
  pages={155-62}
}
OBJECTIVE Low-density lipoprotein receptor-related protein 1 (LRP1), a multifunctional protein involved in endocytosis and cell signaling pathways, leads to several vascular pathologies when deleted in vascular smooth muscle cells (SMCs). The purpose of this study was to determine whether LRP1 deletion in SMCs influenced angiotensin II-induced arterial pathologies. APPROACH AND RESULTS LRP1 protein abundance was equivalent in selected arterial regions, but SMC-specific LRP1 depletion had no… CONTINUE READING

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Association of rs 1466535 LRP 1 but not rs 3019885 SLC 30 A 8 and rs 6674171 TDRD 10 gene polymorphisms with abdominal aortic aneurysm in Italian patients

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