Smooth muscle cell alpha2delta-1 subunits are essential for vasoregulation by CaV1.2 channels.

@article{Bannister2009SmoothMC,
  title={Smooth muscle cell alpha2delta-1 subunits are essential for vasoregulation by CaV1.2 channels.},
  author={John P. Bannister and Adebowale Adebiyi and Guiling Zhao and Damodaran Narayanan and Candice M. Thomas and Jessie Y. Feng and Jonathan H Jaggar},
  journal={Circulation research},
  year={2009},
  volume={105 10},
  pages={948-55}
}
RATIONALE Voltage-dependent L-type (Ca(V)1.2) Ca(2+) channels are a heteromeric complex formed from pore-forming alpha(1) and auxiliary alpha(2)delta and beta subunits. Ca(V)1.2 channels are the principal Ca(2+) influx pathway in arterial myocytes and regulate multiple physiological functions, including contraction. The macromolecular composition of arterial myocyte Ca(V)1.2 channels remains poorly understood, with no studies having examined the molecular identity or physiological functions of… CONTINUE READING