Smooth muscle alpha-actin CArG elements coordinate formation of a smooth muscle cell-selective, serum response factor-containing activation complex.

@article{Mack2000SmoothMA,
  title={Smooth muscle alpha-actin CArG elements coordinate formation of a smooth muscle cell-selective, serum response factor-containing activation complex.},
  author={Christopher P. Mack and Matthew M. Thompson and S C Lawrenz-Smith and Gary K. Owens},
  journal={Circulation research},
  year={2000},
  volume={86 2},
  pages={221-32}
}
Previous studies have shown that multiple serum response factor (SRF)-binding CArG elements were required for smooth muscle cell (SMC)-specific regulation of smooth muscle (SM) alpha-actin expression. However, a critical question remains as to the mechanisms whereby a ubiquitously expressed transcription factor such as SRF might contribute to SMC-specific expression. The goal of the present study was to investigate the hypothesis that SMC-selective expression of SM alpha-actin is due at least… CONTINUE READING