Smoldering Development of Acute Megakaryoblastic Leukemia with Clonal Evolution in an Infant without Down Syndrome.

@article{Schmidt2017SmolderingDO,
  title={Smoldering Development of Acute Megakaryoblastic Leukemia with Clonal Evolution in an Infant without Down Syndrome.},
  author={Eva M. Schmidt and Ute M Fischer and Wolfgang Biskup and Claudia Haferlach and Roland Meisel and Michaela Kuhlen and Arndt Borkhardt},
  journal={Klinische Padiatrie},
  year={2017},
  volume={229 6},
  pages={352-354}
}
The median age of children with AMKL is notably younger (about 1.4 years) than for other AML subtypes (about 10 years) (Schweitzer J et al., Ann Hematol 2015; 94: 1327–1336). In children with Down syndrome (DS), AMKL is the most frequent type of AML with excellent prognosis. It also occurs as de novo leukemia without DS and less often as secondary… CONTINUE READING