Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles.

@article{LinnRasker2006SmokingIA,
  title={Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles.},
  author={S P Linn-Rasker and Annette H van der Helm-van Mil and Floris A van Gaalen and Margreet Kloppenburg and Rene Penning de Vries and Saskia le Cessie and Ferdinand C. Breedveld and Ren{\'e} E M Toes and Tom W. J. Huizinga},
  journal={Annals of the rheumatic diseases},
  year={2006},
  volume={65 3},
  pages={366-71}
}
OBJECTIVES To study the gene-environment interaction of tobacco exposure and shared epitope on autoantibodies in patients with rheumatoid arthritis and undifferentiated arthritis. METHODS From incident cases of arthritis (n = 1305), patients who did not fulfil any classification criteria (undifferentiated arthritis (n = 486)) and those who fulfilled the American College of Rheumatology criteria for rheumatoid arthritis (n = 407) were identified. IgM rheumatoid factor (RF), anti-cyclic… CONTINUE READING

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