Smoking habit, immune suppression, oral contraceptive use, and hormone replacement therapy use and cervical carcinogenesis: a review of the literature

@article{Gadducci2011SmokingHI,
  title={Smoking habit, immune suppression, oral contraceptive use, and hormone replacement therapy use and cervical carcinogenesis: a review of the literature},
  author={Angiolo Gadducci and Cecilia Barsotti and Stefania Cosio and Lavinia Domenici and Andrea Riccardo Genazzani},
  journal={Gynecological Endocrinology},
  year={2011},
  volume={27},
  pages={597 - 604}
}
High-risk human papillomaviruses (HPVs) are involved in the etiopathogenesis of cervical intraepithelial neoplasia (CIN) and cervical cancer. After taking HPV into account, smoking habit appears to be the most significant environmental risk factor, and the risk of this malignancy increases significantly with intensity and duration of smoking. Women with human immunodeficiency virus (HIV) infection experience a higher incidence of CIN and invasive cervical cancer. Among HIV+ women, the highly… Expand
Association of Combined Tobacco Smoking and Oral Contraceptive Use With Cervical Intraepithelial Neoplasia 2 or 3 in Korean Women
TLDR
OC use and smoking acted synergistically to increase the risk of CIN 2 or 3 in Korean women according to additive and multiplicative scales. Expand
A Review of Dietary Prevention of Human Papillomavirus-Related Infection of the Cervix and Cervical Intraepithelial Neoplasia
TLDR
Although it appears that intake of specific nutrients, vitamins, and minerals may be good in CIN prevention, there is lack of evidence from controlled trial to confirm this, and health professionals shall focus on implementation of a balanced-diet prevention strategy at an early stage for cervical cancer prevention. Expand
Estro-progestin Contraceptives and Risk of Cervical Cancer: A Debated Issue
Steroid contraceptive hormones may promote human papilloma virus (HPV) - DNA integration into the host genome, may bind to specific HPV-DNA sequences within transcriptional regulatory regions, andExpand
The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort
TLDR
The results suggest that several hormonal factors are risk factors for cervical carcinogenesis and adherence to current cervical cancer screening guidelines should minimize the increased risk of CC associated with these hormonal risk factors. Expand
Condom and oral contraceptive use and risk of cervical intraepithelial neoplasia in Australian women
TLDR
Use of oral contraceptives, but not condoms, for contraception appeared to be inversely associated with CIN, and prolonged use of oral contraceptive demonstrated its benefits of reducing the risk of CIN. Expand
Risk Factors for Cervical Cancer : Diagnosis and Management
Cervical cancer is the fourth cause of cancer worldwide, and is a common cause of cancer in the low-income countries. Risk factors for cervical cancer include Human papillomavirus (HPV) infection,Expand
Is smoking an independent risk factor for developing cervical intra-epithelial neoplasia and cervical cancer? A systematic review and meta-analysis
TLDR
It is concluded that smoking increases the risk of cervical abnormalities and the high risk of bias indicates that for future studies, it will be important to adjust for relevant predictors, to separate CIN from cervical cancer as outcome measures, and to report research methods in detail. Expand
Relationship between contraceptive methods and human papillomavirus positivity
TLDR
Women aged 30–65 years who admitted to Family Planing outpatient clinic and have hrHPVDNA positivity underwent cervical cancer screening using HPV screening test conducted by the Cancer Control Department of the Ministry of Health, and the two most common HPV genotypes were HPV16 and HPV51. Expand
Association of Combined Tobacco Smoking, Hormonal Contraceptive use and Status Matrimonial with Cervical Cancer Evolution in Tunisian Women
TLDR
In this Tunisian cohort, oral contraception, smoking habit and matrimonial status are associated with an overall increased risk of CC development and may damage the local immunity system and may affect the disease severity in patient carriers of some genetic risk biomarkers. Expand
Persistent oral human papillomavirus infection is associated with smoking and elevated salivary immunoglobulin G concentration.
TLDR
Smoking is a risk factor for a persistent oral HPV infection and Oral HPV infection may be associated with increased concentrations of salivary IgG and lysozyme, according to a nested case-control study of the Finnish Family HPV Study. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 133 REFERENCES
Smoking, diet, pregnancy and oral contraceptive use as risk factors for cervical intra-epithelial neoplasia in relation to human papillomavirus infection
TLDR
Smoking appeared to be the most significant environmental risk factor for cervical neoplasia after taking HPV into account. Expand
Chapter 3: Cofactors in human papillomavirus carcinogenesis--role of parity, oral contraceptives, and tobacco smoking.
TLDR
It can be concluded that high parity, smoking, and less consistently long-term OC use are cofactors that may modulate the risk of progression from HPV infection to HSIL/CC, and multiparous women, women who are smokers, and women on long- term OC use may need closer surveillance for cytologic abnormalities and HPV infections than women in the general population. Expand
The role of steroid contraceptive hormones in the pathogenesis of invasive cervical cancer: A review
TLDR
Experimental evidence has revealed that high–risk type HPV 16 are able to stimulate the development of vaginal and cervical squamous cell carcinomas in transgenic mice exposed to slow-release pellets of 17 β-estradiol in the presence of human keratin-14 promoter. Expand
The biological role of smoking, oral contraceptive use and endogenous sexual steroid hormones in invasive squamous epithelial cervical cancer.
TLDR
The recent finding of a positive correlation between serum estradiol/progesterone ratio and length of survival in premenopausal women with invasive cervical cancer might add further knowledge, if confirmed by larger studies. Expand
Cervical cancer and use of hormonal contraceptives: a systematic review
TLDR
Although long duration use of hormonal contraceptives is associated with an increased risk of cervical cancer, the public health implications of these findings depend largely on the extent to which the observed associations remain long after use oformonal contraceptives has ceased, and this cannot be evaluated properly from published data. Expand
The association of hormonal contraceptive use and HPV prevalence
TLDR
The use of COCs for >6 years was found to be associated with an increased risk of infection with any HPV and any HR‐HPV and data suggest that COC use may impact early upstream events in the natural history of HPV infection. Expand
Effect of oral contraceptives on risk of cervical cancer in women with human papillomavirus infection: the IARC multicentric case-control study
TLDR
Long-term use of oral contraceptives could be a cofactor that increases risk of cervical carcinoma by up to four-fold in women who are positive for cervical HPV DNA. Expand
The Epidemiology of Human Papillomavirus Infection and Cervical Cancer
TLDR
Women exposed to the Human Immunodeficiency Virus (HIV) are at high risk for HPV infection, HPV DNA persistency and progression of HPV lesions to cervical cancer. Expand
Risk of invasive cancer of the cervix in relation to the use of injectable progestogen contraceptives and combined estrogen/progestogen oral contraceptives (South Africa)
TLDR
The present findings suggest that neither injectable progestogen-only nor combined estrogen/progestogen oral contraceptives increase the risk of clinically evident invasive cancer of the cervix. Expand
Combined oral contraceptives and cervical cancer
  • J. Moodley
  • Medicine
  • Current opinion in obstetrics & gynecology
  • 2004
TLDR
These findings seem biologically plausible, but weighing the various risks and benefits, the World Health Organization does not recommend any change in oral contraceptive use or practice. Expand
...
1
2
3
4
5
...