Smoking during pregnancy and congenital limb deficiency.

  title={Smoking during pregnancy and congenital limb deficiency.},
  author={Andrew Endre Czeizel and I Kodaj and Widukind Lenz},
  volume={308 6942},
OBJECTIVE To examine genetic and environmental factors in the origin of isolated congenital limb deficiencies. DESIGN Case-control study with questionnaire at a family interview of cases of isolated congenital limb deficiencies (six types), negative controls (matched for age, sex, and place of residence), and positive controls (cases of sentinel anomalies). SETTING The database of the Hungarian Congenital Abnormality Registry, 1975-84, complemented by three other sources of ascertainment (1… CONTINUE READING


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