Smoking during pregnancy: lessons learned from epidemiological studies and experimental studies using animal models

  title={Smoking during pregnancy: lessons learned from epidemiological studies and experimental studies using animal models},
  author={Louise C. Abbott and Ursula H. Winzer-Serhan},
  journal={Critical Reviews in Toxicology},
  pages={279 - 303}
Numerous epidemiological studies in the human population clearly indicate that smoking while pregnant has deleterious effects on fetal development as well as long-term adverse consequences on postnatal development and maturation of several organ systems. Low birth weight, sudden infant death syndrome (SIDS), behavioral disorders including attention deficit hyperactivity disorder (ADHD), externalizing and internalizing behavioral problems and conduct disorders in children have all been linked to… 

Prenatal nicotine exposure in rodents: why are there so many variations in behavioral outcomes?

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    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
  • 2019
How variations in the nicotine administration methods, timing of nicotine exposure, and species employed could contribute to the disparate findings in outcomes for PNE offspring, both in behavior and neuronal changes is discussed.

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Fetal and neonatal exposure to the smoking cessation drug bupropion, unlike NRT, does not appear to adversely affect metabolic outcomes or the fertility of the female offspring, however, buPropion does appear to alter pubertal onset through an as yet unknown mechanism.

Developmental Consequences of Fetal Exposure to Drugs: What We Know and What We Still Must Learn

Current knowledge on how alcohol, nicotine, cocaine, amphetamine, Ecstasy, and opiates produce alterations in neurodevelopmental trajectory is described, both on animal models and available clinical and imaging data from cross-sectional and longitudinal human studies.

Prenatal tobacco smoke exposure, risk of schizophrenia, and severity of positive/negative symptoms

Smoking and Tobacco Use: Ill Effects on Reproductive, Maternal, Newborn, Child Health, and Adolescent (RMNCHA) Program—A Review

  • S. Mittal
  • Medicine
    Annals of the National Academy of Medical Sciences (India)
  • 2019
Current research evidence from literature search to date has summarized the current research evidence on tobacco use, its effects on male and female fertility, pregnancy and their progeny in utero, neonatal period, childhood, adolescence, and subsequent well-being, with both active and passive smoking and smokeless tobacco use.



Long-term consequences of maternal smoking and developmental chronic nicotine exposure.

  • U. Winzer-Serhan
  • Psychology, Medicine
    Frontiers in bioscience : a journal and virtual library
  • 2008
It remains to be seen if maternal smoking or NRT, would have similar long-term effects in children, and if nicotine is involved in the increased risk to develop ADHD and how developmental nicotine leads to increased anxiety.

In utero nicotine exposure causes persistent, gender-dependant changes in locomotor activity and sensitivity to nicotine in C57Bl/6 mice

Behavioral and neural consequences of prenatal exposure to nicotine.

Prenatal exposure to nicotine may lead to dysregulation in neurodevelopment and can indicate higher risk for psychiatric problems, including substance abuse.

Long-Term Consequences of Fetal and Neonatal Nicotine Exposure: A Critical Review

The long-term effects of fetal and neonatal nicotine exposure on postnatal health will be examined, including the impact of nicotine alone on impaired fertility, type 2 diabetes, obesity, hypertension, neurobehavioral defects, and respiratory dysfunction.

Risks and Benefits of Nicotine to Aid Smoking Cessation in Pregnancy

A national registry for NRT use during pregnancy should be created to prospectively collect obstetrical outcome data from NRT efficacy trials and from individual use to determine the safety of NRTUse during pregnancy, especially with respect to uncommon outcomes such as placental abruption.

Nicotine exposure during the neonatal brain growth spurt produces hyperactivity in preweanling rats.

Environmental tobacco smoke and sudden infant death syndrome: a review.

  • M. Adgent
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    Birth defects research. Part B, Developmental and reproductive toxicology
  • 2006
Evidence indicates that prenatal and postnatal exposures to nicotine do occur from ETS exposure, but that the level of exposure is often substantially less than levels induced by active maternal smoking.

Life-long Programming Implications of Exposure to Tobacco Smoking and Nicotine Before and Soon After Birth: Evidence for Altered Lung Development

  • G. MaritzR. Harding
  • Medicine
    International journal of environmental research and public health
  • 2011
Current knowledge of the effects of nicotine on lung development does not support the use of nicotine replacement therapy in exposed offspring, and the evidence that smoking can have life-long, programming consequences for exposed offspring is considered.

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