Smoking-associated bulky DNA adducts in bronchial tissue related to CYP1A1 MspI and GSTM1 genotypes in lung patients.

@article{Schoket1998SmokingassociatedBD,
  title={Smoking-associated bulky DNA adducts in bronchial tissue related to CYP1A1 MspI and GSTM1 genotypes in lung patients.},
  author={Bernadette Schoket and David H Phillips and Szil{\'a}rd Kostic and Ir{\'e}n Vincze},
  journal={Carcinogenesis},
  year={1998},
  volume={19 5},
  pages={841-6}
}
Relationships between smoking status and levels of bulky DNA adducts were investigated in bronchial tissue of lung patients in relation to their GSTM1 and CYP1A1 MspI genotypes. A total of 150 Hungarian patients undergoing pulmonary surgery were included in the study, 124 with lung malignancies and 26 with non-malignant lung conditions. There were significant relationships between smoking status and bulky DNA adduct levels, as determined by 32P-post-labelling analysis, in macroscopically normal… CONTINUE READING

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