Smoking and therapeutic response to clozapine in patients with schizophrenia.

  title={Smoking and therapeutic response to clozapine in patients with schizophrenia.},
  author={J P Mcevoy and Oliver Freudenreich and William H. Wilson},
  journal={Biological psychiatry},
  volume={46 1},
BACKGROUND Of patients with schizophrenia, 70 to 80% smoke. Nicotine corrects certain information processing and cognitive psychomotor deficits seen in many patients with schizophrenia. Clozapine, but not conventional antipsychotics, has been shown to correct some of these deficits. METHODS We assessed psychopathology and smoking in 70 patients with treatment refractory schizophrenia (55 smokers and 15 nonsmokers) at baseline when they were receiving conventional antipsychotics and again… CONTINUE READING

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