Smoking and the risk of amyotrophic lateral sclerosis: a systematic review and meta-analysis

@article{Alonso2010SmokingAT,
  title={Smoking and the risk of amyotrophic lateral sclerosis: a systematic review and meta-analysis},
  author={{\'A}lvaro Alonso and Giancarlo Logroscino and Miguel A. Hern{\'a}n},
  journal={Journal of Neurology, Neurosurgery \& Psychiatry},
  year={2010},
  volume={81},
  pages={1249 - 1252}
}
Background Epidemiologic studies have provided inconsistent results on the association of cigarette smoking with the incidence of amyotrophic lateral sclerosis (ALS). To summarise published evidence and explore sources of heterogeneity, we conducted a systematic review and meta-analysis of studies that evaluated this association. Methods Published studies evaluating the association of smoking with incidence of ALS were searched in bibliographic databases, with relevant information collected… 

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References

SHOWING 1-10 OF 49 REFERENCES

Prospective study of cigarette smoking and amyotrophic lateral sclerosis.

Limited evidence is provided that current cigarette smoking may be associated with increased death rates from ALS in women but not in men, and the difference in the relative risk estimates between the sexes was statistically significant.

Smoking, Snuff Dipping and the Risk of Amyotrophic Lateral Sclerosis – A Prospective Cohort Study

This study provides no evidence that smoking or snuff dipping is associated with an increased ALS risk among men, and further stratified analyses of smoking status or types of tobacco smoking did not reveal any excess risks in any strata.

Association of Cigarette Smoking with Amyotrophic Lateral Sclerosis

The relationship between amyotrophic lateral sclerosis and cigarette smoking in a case-control study conducted in New England from 1993 to 1996 was explored, and the weak relationship of ALS with alcohol use was apparently due to confounding by smoking.

Prospective study of chemical exposures and amyotrophic lateral sclerosis

Evidence was found, suggesting an increased risk of ALS with formaldehyde exposure, and this result is unlikely to be due to bias, but should nevertheless be interpreted cautiously and needs to be verified independently.

Population-based case-control study of amyotrophic lateral sclerosis in western Washington State. I. Cigarette smoking and alcohol consumption.

The finding that cigarette smoking is a risk factor for ALS is consistent with current etiologic theories that implicate environmental chemicals and oxidative stress in the pathogenesis of ALS.

Population-based case-control study of amyotrophic lateral sclerosis in western Washington State. II. Diet.

A positive association with glutamate intake is consistent with the etiologic theory that implicates glutamate excitotoxicity in the pathogenesis of ALS, whereas the associations with fat and fiber intake warrant further study and biologic explanation.

An Evidence-Based Medicine Approach to the Evaluation of the Role of Exogenous Risk Factors in Sporadic Amyotrophic Lateral Sclerosis

Evidence supported the conclusion that the following were probably not risk factors for ALS: trauma, physical activity, residence in rural areas and alcohol consumption, and evidence in support of smoking being a probable (‘more likely than not’) risk factor for ALS.

Lead Exposure as a Risk Factor for Amyotrophic Lateral Sclerosis

Background: The etiology of amyotrophic lateral sclerosis (ALS) likely involves an environmental component. We qualitatively assessed literature on ALS and lead exposure. Problems of study design

An exploratory case-control study on spinal and bulbar forms of amyotrophic lateral sclerosis in the province of Rome

  • A. BinazziS. Belli ALS Rome Group
  • Medicine
    Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
  • 2009
Several environmental and life-style factors reported as possibly associated with ALS have been analysed in the present study, focusing on the two clinical onsets of ALS. A case-control study (77