Smoking and peripheral type of cancer are related to high levels of pulmonary cytochrome P450IA in lung cancer patients.

@article{Anttila1991SmokingAP,
  title={Smoking and peripheral type of cancer are related to high levels of pulmonary cytochrome P450IA in lung cancer patients.},
  author={Sisko Anttila and Eino K Hietanen and Harri Vainio and Ana Mar{\'i}a Camus and H. V. Gelboin and Seok Soon Park and Lasse Kustaa Heikkil{\"a} and Antti Valtteri Karjalainen and Helmut Bartsch},
  journal={International journal of cancer},
  year={1991},
  volume={47 5},
  pages={
          681-5
        }
}
A specific member of the cytochrome P450 superfamily of enzymes, designated P450IA (including 2 isozymes, P450IA1 and P450IA2), which is involved in the metabolic activation of polycyclic aromatic hydrocarbons and aromatic amines, was studied in lung tissue from 25 lung cancer patients by immunohistochemistry. The pulmonary activity of a P450IA1-dependent enzyme, aryl hydrocarbon hydroxylase (AHH), from the same patients was also measured. Cytochrome P450IA was localized principally in the… CONTINUE READING
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