Smoking and cancer-related gene expression in bronchial epithelium and non-small-cell lung cancers.

@article{Woenckhaus2006SmokingAC,
  title={Smoking and cancer-related gene expression in bronchial epithelium and non-small-cell lung cancers.},
  author={Matthias Woenckhaus and Ludger Klein-Hitpass and Ulrike Grepmeier and Johannes Merk and Marco Pfeifer and Pj Wild and Marcus Bettstetter and P. -H. W{\"u}nsch and Hagen J. Blaszyk and Arndt Hartmann and Ferdinand Hofstaedter and Wolfgang Dietmaier},
  journal={The Journal of pathology},
  year={2006},
  volume={210 2},
  pages={192-204}
}
Tobacco smoking is the leading cause of lung cancer worldwide. Gene expression in surgically resected and microdissected samples of non-small-cell lung cancers (18 squamous cell carcinomas and nine adenocarcinomas), matched normal bronchial epithelium, and peripheral lung tissue from both smokers (n = 22) and non-smokers (n = 5) was studied using the Affymetrix U133A array. A subset of 15 differentially regulated genes was validated by real-time PCR or immunohistochemistry. Hierarchical cluster… CONTINUE READING
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