Smoking and Parkinson’s and Alzheimer’s disease: review of the epidemiological studies

@article{Fratiglioni2000SmokingAP,
  title={Smoking and Parkinson’s and Alzheimer’s disease: review of the epidemiological studies},
  author={Laura Fratiglioni and Hui-Xin Wang},
  journal={Behavioural Brain Research},
  year={2000},
  volume={113},
  pages={117-120}
}

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It appears that this study includes the largest group of Alzheimer’s disease patients studied with respect to smoking, and findings indicate that people who used tobacco developed Alzheimer‘s disease an average of two years earlier, but these findings were not statistically significant.
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A protective association of cigarette smoking for Parkinson's disease may constitute an important etiologic clue.
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The “dose response” pattern showed the greatest risk reduction among those who smoked least and suggests a biologic mechanism of a dose-dependent up-regulation of nicotinic (cholinergic) brain receptors.
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