Smoking, obesity, and hypertension alter the dose-response curve and test sensitivity of carbohydrate-deficient transferrin as a marker of alcohol intake.

@article{Whitfield1998SmokingOA,
  title={Smoking, obesity, and hypertension alter the dose-response curve and test sensitivity of carbohydrate-deficient transferrin as a marker of alcohol intake.},
  author={John B. Whitfield and Linda Maria Fletcher and Therese Luna Murphy and Lawrie William Powell and Jennifer Halliday and A Christopher Heath and Nicholas G. Martin},
  journal={Clinical chemistry},
  year={1998},
  volume={44 12},
  pages={2480-9}
}
Serum carbohydrate-deficient transferrin (CDT) is a specific and comparatively sensitive marker of excessive alcohol use; however, reports of its sensitivity vary according to the population or patient groups studied and their average alcohol intake. We have characterized the dose-response curve between alcohol intake and CDT concentrations in a study of 1400 men and women from a community-based twin registry. Our results show that mean CDT increases with increasing reported alcohol consumption… CONTINUE READING

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