Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain.

@article{Miksys2003SmokingAA,
  title={Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain.},
  author={Sharon Miksys and Caryn Lerman and Peter G. Shields and Deborah C. Mash and Rachel F. Tyndale},
  journal={Neuropharmacology},
  year={2003},
  volume={45 1},
  pages={122-32}
}
CYP2B6 metabolizes drugs such as nicotine and bupropion, and many toxins and carcinogens. Nicotine induces CYP2B1 in rat brain and in humans polymorphic variation in CYP2B6 affects smoking cessation rates. The aim of this study was to compare CYP2B6 expression in brains of human smokers and non-smokers and alcoholics and non-alcoholics (n=26). CYP2B6 expression was brain region-specific, and was observed in both neurons and astrocytes. CYP2B6 levels were higher in brains of smokers and… CONTINUE READING