Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case–control study

@inproceedings{Fisher2015SmokingPG,
  title={Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case–control study},
  author={Benjamin A Fisher and Alison J. Cartwright and Anne-Marie Quirke and P Puyalto de Pablo and Dora Romaguera and Salvatore Panico and Amalia Mattiello and Diana Gavrila and Carmen Navarro and Carlotta Sacerdote and Paolo Vineis and Rosario Tumino and David Francis Lappin and Danae Apazidou and Shauna Culshaw and Jan Potempa and Dominique S. Michaud and Elio Riboli and Patrick J W Venables},
  booktitle={BMC musculoskeletal disorders},
  year={2015}
}
BACKGROUND Antibodies to citrullinated proteins (ACPA) occur years before RA diagnosis. Porphyromonas gingivalis expresses its own peptidylarginine deiminase (PPAD), and is a proposed aetiological factor for the ACPA response. Smoking is a risk factor for both ACPA-positive RA and periodontitis. We aimed to study the relation of these factors to the risk of… CONTINUE READING