Smoked heroin self-administration in rhesus monkeys

@article{Mattox1996SmokedHS,
  title={Smoked heroin self-administration in rhesus monkeys},
  author={Adande J. Mattox and Marilyn Carroll},
  journal={Psychopharmacology},
  year={1996},
  volume={125},
  pages={195-201}
}
The purpose of the present study was to evaluate behavioral and pharmacological determinants of smoked heroin self-administration. Eight rhesus monkeys were trained to self-administer smoked heroin under a chained fixed-ratio (FR, 64-1024) for lever presses, FR 5 for inhalations schedule during daily experimental sessions. Demand for heroin was determined by plotting consumption (smoke deliveries) as a function of price which was varied by increasing the FR lever press requirement from 64 to… CONTINUE READING

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