SmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC.

@article{Hamel2011SmgGDSIA,
  title={SmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC.},
  author={Brant L. Hamel and Elizabeth Monaghan-Benson and Rafael J. Rojas and Brenda R. S. Temple and Daniel J. Marston and Keith Burridge and John Sondek},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 14},
  pages={12141-8}
}
SmgGDS is an atypical guanine nucleotide exchange factor (GEF) that promotes both cell proliferation and migration and is up-regulated in several types of cancer. SmgGDS has been previously shown to activate a wide variety of small GTPases, including the Ras family members Rap1a, Rap1b, and K-Ras, as well as the Rho family members Cdc42, Rac1, Rac2, RhoA, and RhoB. In contrast, here we show that SmgGDS exclusively activates RhoA and RhoC among a large panel of purified GTPases. Consistent with… CONTINUE READING

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