Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay

@inproceedings{Li2015Smg6Est1LE,
  title={Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay},
  author={Tangliang Li and Yue Shi and Pei Wang and Luis Miguel Guachalla and Baofa Sun and Tjard Joerss and Yu-Sheng Chen and Marco Groth and Anja Krueger and Matthias Platzer and Yun-Gui Yang and Karl Lenhard Rudolph and Zhao-Qi Wang},
  booktitle={The EMBO journal},
  year={2015}
}
Nonsense-mediated mRNA decay (NMD) is a post-transcriptional mechanism that targets aberrant transcripts and regulates the cellular RNA reservoir. Genetic modulation in vertebrates suggests that NMD is critical for cellular and tissue homeostasis, although the underlying mechanism remains elusive. Here, we generate knockout mice lacking Smg6/Est1, a key nuclease in NMD and a telomerase cofactor. While the complete loss of Smg6 causes mouse lethality at the blastocyst stage, inducible deletion… CONTINUE READING
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