Corpus ID: 10143299

Smelling the diagnosis: a review on the use of scent in diagnosing disease.

@article{Bijland2013SmellingTD,
  title={Smelling the diagnosis: a review on the use of scent in diagnosing disease.},
  author={L. R. Bijland and Marije K Bomers and Yvo M Smulders},
  journal={The Netherlands journal of medicine},
  year={2013},
  volume={71 6},
  pages={
          300-7
        }
}
For centuries, our sense of smell has been used as a diagnostic tool in the practice of medicine, be it for recognising gas gangrene on the battle field or diabetic ketoacidosis in the emergency room. In recent decades, many scent detection studies have been performed with human, animal and electronic noses. The ability of humans to diagnose disease by smelling has only rarely been the subject of quantitative studies. Scent detection by animals, on the other hand, has been addressed in several… Expand
Sniffing animals as a diagnostic tool in infectious diseases.
  • E. Cambau, M. Poljak
  • Medicine
  • Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
  • 2019
TLDR
The ultimate goal is to understand the biological background of this animal ability and to characterise specific VOCs that animals are recognising that could allow implementation of scent-based tests for major human pathogens. Expand
COVID-19 detection by dogs: from physiology to field application—a review article
TLDR
The objective of this literature review is to clarify the rationale behind dog’s ability to detect diseases, to assess the possible application for COVID-19 detection and to discuss the evidence available on the matter. Expand
Animal olfactory detection of human diseases: Guidelines and systematic review
TLDR
It is suggested that animal detectors hold promise for certain diagnostic applications but that additional research evaluating operationally viable systems for olfactory detection of human diseases is necessary. Expand
In vitro detection of common rhinosinusitis bacteria by the eNose utilising differential mobility spectrometry
TLDR
Differential mobility spectrometry (DMS) has shown its potential in detecting rhinosinusitis bacteria in vitro and the applicability of DMS needs to be studied with rhinositis patients. Expand
Dogs demonstrate the existence of an epileptic seizure odour in humans
TLDR
Test whether trained dogs, as demonstrated for cancer or diabetes, may discriminate a general epileptic seizure odor, which constitutes a first proof that, despite the variety of seizures and individual odours, seizures are associated with olfactory characteristics. Expand
Canine Detection of the Volatile Organic Compounds Related to Cervical Cancer Cells
TLDR
The great odor detection threshold exhibited by dogs is not unheard of and represents a potential opportunity to develop an affordable, accessible, and non-invasive method for detection of CC with high sensibility and specificity values. Expand
Highly sensitive scent-detection of COVID-19 patients in vivo by trained dogs
TLDR
Canine scent-detection in vivo is a highly accurate screening test for COVID-19, and it detects more than 99% of infected individuals independent of key variables, such as disease prevalence, time post-exposure, or presence of symptoms. Expand
Dog Savior: Immediate Scent-Detection of SARS-COV-2 by Trained Dogs
TLDR
It is shown that viral detection takes one second per specimen, demonstrating that dogs could be useful to track viral infection in humans, allowing COVID-19 free people to return to work safely. Expand
Sniffing 'infection odour': A cross sectional study of odours from patients with infectious disease
TLDR
Physician detectable smell is present only in some people, and there was no relation to the type of infection, temperature, respiratory rate, number of medications, or severity of illness with the smells emanating from the patients. Expand
Highly sensitive scent-detection of COVID-19 patients in vivo by trained dogs
TLDR
Canine scent-detection in vivo is a highly accurate screening test for COVID-19, and it detects more than 99% of infected individuals independently of the key variables, however, real-life conditions increased substantially the number of false positives, indicating the necessity of training a threshold for the limit of detection to discriminate environmental odoriferous contamination from infection. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 54 REFERENCES
Canine scent detection in the diagnosis of lung cancer: revisiting a puzzling phenomenon
TLDR
To test the robustness of the presence of a so far unknown volatile organic compound in the breath of patients with lung cancer, sniffer dogs were applied and lung cancer was identified with an overall sensitivity and a specificity of 93%. Expand
Colorectal cancer screening with odour material by canine scent detection
TLDR
This study shows that a specific cancer scent does indeed exist and that cancer-specific chemical compounds may be circulating throughout the body and these odour materials may become effective tools in CRC screening. Expand
Pouched Rats' Detection of Tuberculosis in Human Sputum: Comparison to Culturing and Polymerase Chain Reaction
TLDR
It is suggested that pouched rats are a valuable adjunct to, and may be a viable substitute for, sputum smear microscopy as a tuberculosis diagnostic in resource-poor countries. Expand
Diagnostic Accuracy of Canine Scent Detection in Early- and Late-Stage Lung and Breast Cancers
TLDR
Training was efficient and cancer identification was accurate; in a matter of weeks, ordinary household dogs with only basic behavioral “puppy training” were trained to accurately distinguish breath samples of lung and breast cancer patients from those of controls. Expand
Diagnosis of Tuberculosis by Trained African Giant Pouched Rats and Confounding Impact of Pathogens and Microflora of the Respiratory Tract
TLDR
Rats' ability to discriminate between clinical sputum containing other Mycobacterium spp. Expand
Evidence for canine olfactory detection of melanoma
Evidence of chemical markers for melanoma in blood and urine suggests that volatile chemicals might be released from melanoma cells (on the skin surface) in amounts sufficient to allow earlyExpand
Using a dog’s superior olfactory sensitivity to identify Clostridium difficile in stools and patients: proof of principle study
TLDR
Whether a dog’s superior olfactory sensitivity can be used to detect Clostridium difficile in stool samples and hospital patients and in patients is investigated. Expand
Characteristic odour in the blood reveals ovarian carcinoma
TLDR
It is strongly suggested that the characteristic odour emitted by ovarian cancer samples is also present in blood (plasma) taken from patients with the disease. Expand
An investigation on electronic nose diagnosis of lung cancer.
TLDR
In this paper an experiment, performed in the bronchoscopy unit of a large hospital, aimed at discriminating between lung cancer, diverse lung diseases and reference controls is illustrated, showing not only a satisfactory identification rate of lung cancer subjects but also a non-negligible sensitivity to breath modification induced by other affections. Expand
Effects of extraneous odors on canine detection
TLDR
The results are described in terns of the ability of dogs to detect target odors in the presence of a wide range of concentrations of the extraneous odors. Expand
...
1
2
3
4
5
...