• Corpus ID: 10143299

Smelling the diagnosis: a review on the use of scent in diagnosing disease.

@article{Bijland2013SmellingTD,
  title={Smelling the diagnosis: a review on the use of scent in diagnosing disease.},
  author={L. R. Bijland and Marije K Bomers and Yvo M Smulders},
  journal={The Netherlands journal of medicine},
  year={2013},
  volume={71 6},
  pages={
          300-7
        }
}
For centuries, our sense of smell has been used as a diagnostic tool in the practice of medicine, be it for recognising gas gangrene on the battle field or diabetic ketoacidosis in the emergency room. In recent decades, many scent detection studies have been performed with human, animal and electronic noses. The ability of humans to diagnose disease by smelling has only rarely been the subject of quantitative studies. Scent detection by animals, on the other hand, has been addressed in several… 

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References

SHOWING 1-10 OF 53 REFERENCES

Colorectal cancer screening with odour material by canine scent detection

This study shows that a specific cancer scent does indeed exist and that cancer-specific chemical compounds may be circulating throughout the body and these odour materials may become effective tools in CRC screening.

Pouched Rats' Detection of Tuberculosis in Human Sputum: Comparison to Culturing and Polymerase Chain Reaction

It is suggested that pouched rats are a valuable adjunct to, and may be a viable substitute for, sputum smear microscopy as a tuberculosis diagnostic in resource-poor countries.

Diagnostic Accuracy of Canine Scent Detection in Early- and Late-Stage Lung and Breast Cancers

Training was efficient and cancer identification was accurate; in a matter of weeks, ordinary household dogs with only basic behavioral “puppy training” were trained to accurately distinguish breath samples of lung and breast cancer patients from those of controls.

Diagnosis of Tuberculosis by Trained African Giant Pouched Rats and Confounding Impact of Pathogens and Microflora of the Respiratory Tract

Rats' ability to discriminate between clinical sputum containing other Mycobacterium spp.

Using a dog’s superior olfactory sensitivity to identify Clostridium difficile in stools and patients: proof of principle study

Whether a dog’s superior olfactory sensitivity can be used to detect Clostridium difficile in stool samples and hospital patients and in patients is investigated.

Characteristic odour in the blood reveals ovarian carcinoma

It is strongly suggested that the characteristic odour emitted by ovarian cancer samples is also present in blood (plasma) taken from patients with the disease.

Effects of extraneous odors on canine detection

The results are described in terns of the ability of dogs to detect target odors in the presence of a wide range of concentrations of the extraneous odors.
...