SmcR and cyclic AMP receptor protein coactivate Vibrio vulnificus vvpE encoding elastase through the RpoS-dependent promoter in a synergistic manner.

@article{Jeong2003SmcRAC,
  title={SmcR and cyclic AMP receptor protein coactivate Vibrio vulnificus vvpE encoding elastase through the RpoS-dependent promoter in a synergistic manner.},
  author={Hye Sook Jeong and Myoung Hee Lee and Kwan-soon Lee and Soon-Jung Park and Sang Ho Choi},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 46},
  pages={
          45072-81
        }
}
The putative virulence factors of Vibrio vulnificus include an elastase, the gene product of vvpE. We previously demonstrated that vvpE expression is differentially directed by two different promoters in a growth phase-dependent manner. The activity of the stationaryphase promoter (promoter S (PS)) is dependent on RpoS and is also under the positive control of cyclic AMP receptor protein (CRP). In this study, primer extension analyses revealed that SmcR, the Vibrio harveyi LuxR homolog, is also… CONTINUE READING

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