Corpus ID: 53613057

Smart polyelectrolyte hydrogels: a novel platform for drug delivery

  title={Smart polyelectrolyte hydrogels: a novel platform for drug delivery},
  author={Mario Casolaro and Ilaria Casolaro},
  journal={Chemical engineering transactions},
Three kinds of vinyl hydrogels with α-aminoacid residues have been considered as potential platforms for the deliver of several therapies (pain, diabetes, and mood) when loaded with appropriate drugs. The presence of ionizable groups of the L-valine, L-phenylalanine and L-histidine residues is able to modify the swelling properties of the hydrogel on the basis of its pKa values. A greater basicity constant of the functional groups improves a greater loading of the drug and a longer sustained… Expand

Figures from this paper


Stimuli-Responsive Hydrogels Bearing ñamino acid Residues: a PotentialPlatform for Future Therapies
Vinyl hydrogels bearing α-aminoacid residues have been explored as platforms for the treatment of cancer, glaucoma and mood disorder therapies. Ionic/ionizable groups of the L-valine, L-phenylalanineExpand
Long-term doxorubicin release from multiple stimuli-responsive hydrogels based on α-amino-acid residues.
In vitro experiments have shown that the released Doxorubicin is able to induce cell death to cervix adenocarcinoma cells (HeLa cells) and the amount of the released DOXO was found in all cases substantially higher than the "control" because the application of the AMF augments in stimulating the nanoparticles within theDOXO-loaded hydrogel. Expand
Stimuli-responsive hydrogels for controlled pilocarpine ocular delivery.
  • M. Casolaro, I. Casolaro, S. Lamponi
  • Chemistry, Medicine
  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2012
A series of vinyl hydrogels containing α-aminoacid (L-histidine, L-valine) residues was synthesized and their swelling properties evaluated at different pHs and temperatures, found to be non-toxic against the mouse fibroblast NIH3T3 cells. Expand
Polyelectrolyte Hydrogel Platforms for the Delivery of Antidepressant Drugs
Some vinyl hydrogels containing α-amino acid residues (l-phenylalanine, l-valine) were used as polyelectrolyte platforms for the evaluation of the controlled release of two antidepressants and paroxetine was found to be slower compared to that of two structurally related drugs bearing the tertiary amino nitrogen atom. Expand
Multiple Stimuli-Responsive Hydrogels for Metal-Based Drug Therapy
A series of homopolymeric and copolymeric hydrogels containing the N-isopropylacrylamide and vinyl monomers with α-amino acid (L-valine and L-phenylalanine) residues have been synthesized and theirExpand
Controlled release of antidepressant drugs by multiple stimuli-sensitive hydrogels based on α-aminoacid residues
Abstract Two slightly cross-linked hydrogels bearing l -phenylalanine (Phe-Nip3) or l -valine (Ava2) residues of a copolymeric and homopolymeric vinyl structure were considered for their potentialExpand
Pulsed release of antidepressants from nanocomposite hydrogels
The pulsed release of three antidepressants loaded on two vinyl hydrogels bearing -amino acid residues and embedded magnetic nanoparticles, evaluated in different buffer solutions of purposely chosen pHs, found that the release of the drug was always small for a long period of days, and it underwent a sudden increase when a solution of pH 7.4 was maintained for a short period of hours. Expand
Hydrogel containing L-valine residues as a platform for cisplatin chemotherapy.
Two acrylic hydrogels, of low cross-linking content and carrying the L-valine residues, were synthesized and studied as a platform to load and release the chemotherapeutic agent cisplatin, showing a well-defined stoichiometric ratio and an interesting synergy in term of cytotoxicity. Expand
Enhanced Pulsatile Drug Release from Injectable Magnetic Hydrogels with Embedded Thermosensitive Microgels
Nanocomposite in situ-gelling hydrogels containing both superparamagnetic iron oxide nanoparticles (SPIONs) and thermoresponsive microgels are demonstrated to facilitate pulsatile, high-low releaseExpand
Controlled release of insulin from pH/temperature-sensitive injectable pentablock copolymer hydrogel.
The results showed that the diabetic rats could be treated for more than 1 week with a single injection of the complex mixture containing 10 mg/mL insulin in a 30 wt.% copolymer solution, suggesting that this pH/temperature-sensitive insulin-hydrogel complex system may have therapeutic potential. Expand